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Materials Research

There are numerous research projects focusing on novel biomaterials for use in matrix manufacturing. These projects include synthetic polymers, ceramics, natural polymers, and their composites. A bone tissue-engineered scaffold is typically biodegradable and osteoconductive. The desired mechanical properties vary according to wound site. Delivery of growth factors from these biomaterials is also being examined. The challenge is to create a biocompatible material that will degrade at a complementary rate to bone formation, with minimal foreign body response. Some projects are relatively new, so they are not linked to a separate project page as yet.


Growth Factor Encapsulation
Biodegradable polymer microspheres and nanospheres are being fabricated for controlled drug delivery applications. Growth factors such as BMP and IGF-I are being encapsulated into PLGA microspheres and incorporated into tissue-engineered scaffolds. (Investigators: Kacey Marra and Yunhua Hu)


Polymer/Ceramic Composites
Biodegradable polymer/ceramic composites are being developed with several goals. The first is to determine a better understanding of the nature of polymer/ceramic interfaces. The second goal is to obtain a bone tissue-engineered substitute with osteoconductive properties as well as superior surgical handling properties. (Investigators: Toby Chapman, Prashant Kumta, and Kacey Marra)

Native Polymers (Hu)