Alan S. Waggoner

Carnegie Mellon
294 Mellon Institute
Pittsburgh, PA 15213
phone: 412-268-3456
email:
waggoner@andrew.cmu.edu

(1965) B.A Chemistry, University of Colorado

(1969) Ph.D, Chemistry,
University of Oregon

(1971) Post Doc,Biophysiscs, Yale University

Alan S. Waggoner
Director of the Center for Light Microscope Imaging and Biotechnology
Professor of Biological Sciences
Carnegie Mellon University

Research Interests
Dr. Waggoner's research has focused on development of fluorescence-based detection systems for biology and biotechnology. In a new optical biosensor initiative, the Waggoner group and its collaborators are creating a fundamental sensor unit technology for a new and very broad class of biosensors. We envision this technology will provide a powerful, and almost generic, tool for detecting a wide range of important biological regulatory molecules, "target molecules", in cells and in the interstitial spaces between cells. The sensors are intended to sensitively and rapidly detect many targets (perhaps hundreds, ultimately) simultaneously in a tissue and will be valuable for development and monitoring of engineered tissues.

Sample Publications
   Randolph JR, Waggoner, AS. Stability, Specificity and Fluorescence Brightness of Multiply-labeled DNA Probes. Nucl. Acids Res. 25:2923-2929 (1997)
    Dow AI, Shafer SA, Kirkwood JM, Mascari RA, Waggoner AS. Automatic Multiparameter Fluorescence Imaging for Determining Lymphocyte Phenotype and Activation Status in Melanoma Tissue Sections. (1995). Cytometry, 25:71-81 (1996)
    Mujumdar SR, Mujumdar RB, Grant CM, Waggoner AS. CyanineLabeling Reagents: Sulfobenzindocyanine Succinimidyl Esters. Bioconj. Chem., 7:356-362 (1996).