Bruce Doll

Carnegie Mellon
125 Smith Hall
Pittsburgh, PA 15213
phone 412-268-7156
email:
bdoll@ux10.sp.cs.cmu.edu

DDS State University of New York

Residency in General Practice, Buffalo General Hospital

Residency in Periodontology, Naval Dental School

Ph.D. The Pennsylvania State University

Bruce Doll
Associate Research Scientist
Bone Tissue Engineering Center (BTEC)
Biomedical and Health Engineering
Carnegie Mellon University

Research Interests
My interests are focused on the feasibility of osteoprogenitor cell activity in a skeletal defect. Various protein factors (parathyroid hormone, bone morphogenetic protein, fibroblast growth factor) have demonstrated effects upon the phenotype. Enhancement of the bone regenerative capability within a bone defect is our goal. Various methods are currently being tested on a surgically created defect. Defects in either rat, dog or monkey are treated with a combinatorial approach. Combinatorial therapies include a scaffold, cells and various factors to amplify the bone generative capacity. Histological, physical chemical, biochemical and molecular biological assessments of the wound healing are employed to optimize therapy. The facilities at the University of Pittsburgh School of Dental Medicine compliment the laboratories in the BTEC.

Sample Publications
   Doll,B.A.; Towle,H.J.; Hollinger,J.; Reddi,H.; Mellonig, J.T. The Osteogenic Potential of Two Composite Graft Systems Using Osteogenin, J.Periodontology 1990; 61:745-750